Сысоева Ольга Владимировна
Институт когнитивных нейронаук
Профессиональные интересы
Должности
- Ведущий научный сотрудник — Институт когнитивных нейронаук, Центр нейроэкономики и когнитивных исследований
- Доцент — Факультет биологии и биотехнологии, Базовая кафедра Института биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН
Био
- · Начала работать в НИУ ВШЭ в 2015 году.
- · Научно-педагогический стаж: 25 лет.
Образование
- 2004 · Кандидат психологических наук: Московский государственный университет им. М.В. Ломоносова
- 2000 · Специалитет: Московский государственный университет им. М.В. Ломоносова, специальность «Психология», квалификация «Психолог. Преподаватель психологии»
Опыт работы
- · 2015 г.: С НИУ ВШЭ
Идентификаторы исследователя
- ORCID:
0000-0002-4005-9512 - ResearcherID:
F-9301-2019 - SPIN РИНЦ:
2139-6619 - Google Scholar: https://scholar.google.com/citations?user=OununUoAAAAJ&hl=en
- Scopus AuthorID:
18038702800
Публикации (11)
Semantics and Syntax Effects on Event-Related Fields during Speech Comprehension: a MEG Study
2026 в печати · ARTICLE · en
This manuscript fits the scope of Frontiers in Human Neuroscience (Speech and Language) as it investigates the cortical dynamics of speech perception using MEG during naturalistic auditory comprehension. The study examines how semantic dissimilarity and word class modulate MEG event-related fields (ERFs), reflecting aspects of semantic integration and syntactic processing during continuous speech. The results show that semantically distinct words elicit a late ERF increase in left temporal sensors, while function and content words differ in both early and late time windows. Additional analyses confirm that part of the late effect for function words reflects sensitivity to the upcoming word. These findings demonstrate that ERFs during continuous speech are systematically modulated by semantic context and lexical category. The work also illustrates how ERF-based methods can complement convolution and TRF approaches commonly used in natural speech research. This work directly aligns with the Research Topic “The cortical representation of speech perception: Current developments” by providing novel MEG evidence on how the brain encodes semantic context and syntactic structure in ecological listening conditions, thus informing contemporary models of speech comprehension.
Attentional network efficiency in elite biathletes and cross-country skiers
2026 · ARTICLE · en
Данное исследование представляет собой первое изучение эффективности сетей внимания у элитных спортсменов зимних видов спорта - биатлонистов и лыжников. С помощью теста сетей внимания Познера (ANT) мы оценили ориентировочную, сигнальную и исполнительную сети внимания у 44 элитных спортсменов (15 биатлонистов, 29 лыжников) и 20 человек из группы контроля. Результаты показали, что элитные спортсмены в целом продемонстрировали значительно более низкий уровень сигнализации по сравнению с контрольной группой [13.1 ± 2.9 против 25.9 ± 5.2, t(Welsh) (63) = 2.134, p = 0.041, d Кохена = 0.592], что интерпретируется как нейронный признак устойчивой готовности, при которой нервная система постоянно находится в состоянии готовности, уменьшая пользу от внешних сигналов предупреждения. Эта способность проявлялась даже более ярко у биатлонистов, чем у лыжников, и также распространялась на пространственно-временные сигналы [суммарный балл сигнализации и ориентировки: 61.3 ± 9.4 против 90.2 ± 4.7, t(Welsh) (43) = 2.740, p = 0.012, d Кохена = 0.918]. Эта ослабленная реакция на временные и пространственные сигналы рассматривается как обученный "когнитивный щит", позволяющий биатлонистам подавлять автоматические смещения внимания к пространственным сигналам параллельно с поддержанием состояния готовности — критическая адаптация для поддержания точности стрельбы среди физиологического шума и внешних отвлечений при стрельбе под высоким кардиоваскулярным нагрузкам. Различий между группами не было обнаружено в исполнительных сетях внимания и общем времени реакции, что подчеркивает значимость конкретных компонентов внимания для этих видов спорта. Результаты демонстрируют, что архитектура внимания элитных спортсменов не является широко улучшенной, но точно откалибрована в соответствии с уникальными требованиями их спорта, подчеркивая замечательную степень оптимизации производительности под давлением в зависимости от конкретной задачи.
Rapid semantic processing: an MEG study of narrative text reading
2025 · ARTICLE · en
Research has shown that semantic analysis occurs at early stages of word processing (less than 200 ms). While traditional studies have focused on isolated words/sentences, our research explores rapid semantic processing during reading stories when texts were presented word by word (each word lasting 150 ms), enhancing rapid semantic processing. We sorted words by quartiles according to their semantic dissimilarity (SD) and computed event-related fields (102 magnetometers) in 27 adult participants. Cluster-permutation analysis revealed two significant clusters of brain activity within early time windows (120–132 ms) that differentiated words according to their SD: positive in the right occipital region and negative in the left temporal region. In both clusters less pronounced responses were registered for words with lowest SD which corresponds to theories of predictive coding. These findings broaden our understanding of rapid semantic processing and suggest new methodology to study neurophysiological mechanisms of reading.
Novelty, category and orientation tuning for printed characters: A magnetoencephalography study with fast periodic visual stimulation
2025 · PREPRINT · en
Letter recognition is assumed to involve several levels of analysis, including coarse tuning for category and novelty and more fine tuning, related to letter orientation. We employed an oddball fast periodic visual stimulation (FPVS) paradigm with magnetoencephalography (Elekta VectorView, 306 sensors) to study neural discrimination responses in the source space. Using contrasts between native letters and foreign letters, digits, or inverted native letters, we aimed to isolate the neural responses to visual novelty, category, and orientation during character analysis. The study was conducted with a cohort of 25 adults. The response topography demonstrated bilateral organization, including language-related brain regions as ventral occipitotemporal cortex, inferior parietal cortex and middle temporal areas. Comparing conditions, we revealed right lateralized parietal clusters, associated with novelty tuning, and left lateralized occipitotemporal clusters exhibiting higher activity for letters among digits discrimination, supporting the role of this area in letter processing. No distinct spatial patterns specific to orientation tuning were observed in comparison to novelty and category tuning. We proposed that expertise-dependent orientation-specific tuning mechanisms may operate within an embedded, spatially overlapping with coarse tuning neural framework, characterized by special spatiotemporal patterns.
Developmental Changes in Presentation Rate Effect on Auditory Event-Related Potential through Childhood to Adulthood
2024 · ARTICLE · en
Abstract. In adults, the rate of stimuli presentation has been shown to play a critical role for the event related potentials (ERP): its components become larger as presentation rate decreases. But there are few works evaluating developmental changes of this ERP modulation that might provide insights into basic forms of learning. The current study aims to examine the developmental changes in the effect of the presentation rate on ERP. Participants (N = 48) of four age groups (2–7, 8–11, 12–17 and 18–35 years old) were presented with auditory tone (1000 Hz) at three different stimulus onset asynchrony (SOA): 0.9, 1.8, and 3.6 s. During stimuli presentation 28-channels electroencephalogram (EEG) was recorded. Ampli-tude of ERP components increased with SOA prolongation. However, this effect was diffe- rently pronounced in each of the age groups, depending on the component and cortical site. N1P1 amplitude was increased from 0.9 to 1.8 s SOA in two oldest groups (12–17 years old and adults) predominantly at fronto-central sites. Similar increase demonstrated P2N1 com-ponent but starting from younger group (8–11 years old). Only the adult group was character-ized by a significant increase in N1P1 and P2N1 amplitudes with SOA increase from 1.8 to 3.6 s. Thus, the effect of presentation rate on ERP is not fully mature even at adolescence and depends on the component with P2N1 amplitude showing modulations at younger age.
Atypical brain responses to 40-Hz click trains in girls with Rett syndrome: Auditory steady-state response and sustained wave
2024 · ARTICLE · en
Aim: The current study aimed to infer neurophysiological mechanisms of auditory processing in children with Rett syndrome (RTT)-rare neurodevelopmental disorders caused by MECP2 mutations. We examined two brain responses elicited by 40-Hz click trains: auditory steady-state response (ASSR), which reflects fine temporal analysis of auditory input, and sustained wave (SW), which is associated with integral processing of the auditory signal. Methods: We recorded electroencephalogram findings in 43 patients with RTT (aged 2.92-17.1 years) and 43 typically developing children of the same age during 40-Hz click train auditory stimulation, which lasted for 500 ms and was presented with interstimulus intervals of 500 to 800 ms. Mixed-model ancova with age as a covariate was used to compare amplitude of ASSR and SW between groups, taking into account the temporal dynamics and topography of the responses. Results: Amplitude of SW was atypically small in children with RTT starting from early childhood, with the difference from typically developing children decreasing with age. ASSR showed a different pattern of developmental changes: the between-group difference was negligible in early childhood but increased with age as ASSR increased in the typically developing group, but not in those with RTT. Moreover, ASSR was associated with expressive speech development in patients, so that children who could use words had more pronounced ASSR. Conclusion: ASSR and SW show promise as noninvasive electrophysiological biomarkers of auditory processing that have clinical relevance and can shed light onto the link between genetic impairment and the RTT phenotype.
Lower loss rate of serotonergically modulated neuronal accumulator for time in patients with major depressive disorder
2023 · ARTICLE · en
Major depressive disorder (MDD) is characterized by dramatic and persistent worsening of mood, as well as a subjective feeling of time slowing. However, experimental data on time perception are inconsistent. As serotonergic dysfunction implicated in MDD etiology, we aim to examine time perception in MDD through the framework of lossy temporal integration model, previously also related to serotonergic transmission. Thirty-one patients with recurrent depressive disorder in partial remission and thirty control participants, without a history of psychiatric and neurological disorders, performed duration discrimination of visual stimuli (duration ranges from 3.2 to 6.4 s) and subjective minute production tasks. To infer about central serotonergic transmission, an electroencephalogram in response to the 1000 Hz tone of different intensity (50, 60, 70 and 80 dB SPL) was recorded. Patients with MDD shorten the past durations in the duration discrimination task significantly less than controls, thus being more objective. No difference in the subjective minute production was recorded. Patients with MDD have also exhibited larger auditory evoked potentials in response to the tones of high intensity (70 and 80 dB SPL) when compared with the controls. This resulted in a steeper slope of auditory evoked potentials by intensity function. These converging findings suggest a lower loss rate of neuronal temporal accumulator modulated by serotonergic transmission in patients with MDD.
Opposite effects of rapid auditory stimulation on tetanized and non-tetanized tone of adjacent frequency: Mismatch negativity study
2023 · ARTICLE · en
Our study describes the effects of sensory tetanization on neurophysiological and behavioral measures in humans linking cellular studies of long-term potentiation with high-level brain processes. Rapid (every 75ms) presentation of pure tone (1020 Hz, 50ms) for 2 minutes was preceded and followed by oddball blocks that contained the same stimulus presented as deviant (probability of 5–10%) interspersed with standard (80–90%) and deviant tones (5–10%) of adjacent frequencies (1000 and 980Hz, respectively). Mismatch negativity (MMN) component in response to tetanized tone (1020Hz), while being similar to MMN for non-tetanized tone before tetanization, became larger than that after tetanization, pointing to the increase in cortical differentiation of these tones. However, this differentiation was partially due to the MMN decrease after tetanization for tones adjacent to tetanized frequency, suggesting the influence of lateral inhibition to this effect. Although MMN correlated with tone discriminability in a psychophysical task, the behavioral improvement after tetanization was not statistically detectable. To conclude, short-term auditory tetanization affects cortical representation of tones that are not limited to the tetanized stimuli.
Generalization of sustained neurophysiological effects of short-term auditory 13-Hz stimulation to neighbouring frequency representation in humans
2022 · ARTICLE · en
A fuller understanding of the effects of auditory tetanization in humans would inform better language and sensory learning paradigms; however, there are still unanswered questions. Here, we probe sustained changes in the event-related potentials (ERPs) to 1020- and 980-Hz tones following a rapid presentation of 1020-Hz tone (every 75 ms, 13.3 Hz, tetanization). Consistent with some previous studies, we revealed the increase in the P2 ERP component after tetanization. Contrary to some other studies, we did not observe the expected N1 increase after tetanization even in the identical experimental sequence. We detected a significant N1 decrease after tetanization. Expanding previous research, we showed that P2 increase and N1 decrease are not specific to the stimulus type (tetanized 1020 Hz and non-tetanized 980 Hz), suggesting the generalizability of tetanization effect to the not-stimulated auditory tones, at least to those of the neighbouring frequency. The ERPs' tetanization effects were observed for at least 30 min—the most prolonged interval examined, consistent with the duration of long-term potentiation, LTP. In addition, the tetanization effects were detectable in the blocks where the participants watched muted videos, an experimental setting that can be easily used in children and other challenging groups. Thus, auditory 13-Hz stimulation affects brain processing of tones including those of neighbouring frequencies.
A Toolbox and Crowdsourcing Platform for Automatic Labeling of Independent Components in Electroencephalography
2021 · ARTICLE · en
Independent Component Analysis (ICA) is a conventional approach to exclude non-brain signals such as eye movements and muscle artifacts from electroencephalography (EEG). A rejection of independent components (ICs) is usually performed in semiautomatic mode and requires experts’ involvement. As also revealed by our study, experts’ opinions about the nature of a component often disagree, highlighting the need to develop a robust and sustainable automatic system for EEG ICs classification. The current article presents a toolbox and crowdsourcing platform for Automatic Labeling of Independent Components in Electroencephalography (ALICE) available via link http://alice.adase.org/. The ALICE toolbox aims to build a sustainable algorithm to remove artifacts and find specific patterns in EEG signals using ICA decomposition based on accumulated experts’ knowledge. The difference from previous toolboxes is that the ALICE project will accumulate different benchmarks based on crowdsourced visual labeling of ICs collected from publicly available and in-house EEG recordings. The choice of labeling is based on the estimation of IC time-series, IC amplitude topography, and spectral power distribution. The platform allows supervised machine learning (ML) model training and re-training on available data subsamples for better performance in specific tasks (i.e., movement artifact detection in healthy or autistic children). Also, current research implements the novel strategy for consentient labeling of ICs by several experts. The provided baseline model could detect noisy IC and components related to the functional brain oscillations such as alpha and mu rhythm. The ALICE project implies the creation and constant replenishment of the IC database, which will improve ML algorithms for automatic labeling and extraction of non-brain signals from EEG. The toolbox and current dataset are open-source and freely available to the researcher community.
Курсы (3)
-
Нейробиология развития · 2 раза
2025/2026, 2024/2025 · Бакалавриат · рус
-
Advanced Behavioural Genetics · 2 раза
2022/2023, 2021/2022 · Магистратура / Маго-лего · Анг
-
Научно-исследовательский семинар "Актуальные вопросы когнитивных нейронаук"
2022/2023 · Бакалавриат · рус