Миннигулова Алина Шамилевна
Центр языка и мозга
Профессиональные интересы
Должности
- Научный сотрудник — Центр языка и мозга
Био
- · Начала работать в НИУ ВШЭ в 2020 году.
- · Научно-педагогический стаж: 3 года.
Образование
- 2022 · Магистратура: Национальный исследовательский университет "Высшая школа экономики", специальность «Психология», квалификация «Магистр»
- 2020 · Бакалавриат: Национальный исследовательский университет "Высшая школа экономики", специальность «Фундаментальная и прикладная лингвистика», квалификация «Бакалавр»
Опыт работы
- · 2020-2022: стажер исследователь Центра языка и мозга, НИУ ВШЭ
- · 2023: младший научный сотрудник Центра языка и мозга, НИУ ВШЭ
- · 2024-н.в.: научный сотрудник Центра языка и мозга, НИУ ВШЭ
Награды и поощрения
- · Надбавка за публикации, вносящие особый вклад в международную научную репутацию НИУ ВШЭ (2024–2026, 2023–2026)
- · Группа высокого профессионального потенциала (кадровый резерв НИУ ВШЭ)Категория "Новые исследователи" (2022–2023)
Конференции (1)
Показать все
- · 2023: Psycholinguistic, neurolinguistic and clinical linguistic research (Нови-Сад). Доклад: Thalamus organization in children with ASD
Идентификаторы исследователя
- ORCID:
0000-0002-5568-8311 - ResearcherID:
AAU-7455-2021 - Google Scholar: https://scholar.google.com/citations?view_op=list_works&hl=ru&user=g59BXWEAAAAJ
- Scopus AuthorID:
57222504971
Публикации (14)
Применение методик кортикальной и субкортикальной стимуляции у пациентов с глиальными опухолями различной степени злокачественности доминантного по речи полушария головного мозга в условиях хирургии с пробуждением.
2026 · ARTICLE · ru
Введение. Применение кортикальной и субкортикальной стимуляции в процессе операции с пробуждением снижает риск появления стойкого дефицита речи после операции. Однако функция отдельных проводящих путей белого вещества до сих пор недостаточно изучена, особенно в отношении значимости лобного косого пучка (FAT) доминантного полушария. Цель исследования – анализ опыта применения методов кортикальной и субкортикальной стимуляции при локализации глиальных опухолей вблизи речевых центров и трактов (SLF / AF, FAT) в условиях хирургии с пробуждением. Материалы и методы. 17 пациентов (6 мужчин, 11 женщин) прооперированы с использованием методики интраоперационного пробуждения в ФГБУ «Федеральный центр нейрохирургии» Минздрава России г. Новосибирска в период с 2020 по 2023 г. У всех пациентов до, после операции и в катамнезе осуществлена оценка неврологического, нейролингвистического статусов, а также выполнена МР-трактография. Построение трактов и волюметрия опухолей осуществлены с использованием полуавтоматических методов сегментации на рабочей станции “BrainLab”. Результаты. При использовании субкортикальной биполярной стимуляции и постоянной монополярной стимуляции средняя степень резекции (EOR) составила 89 % (межквартильный размах IQR = 26, Q1 = 74, Q3 = 100). Временный речевой дефицит развился у 10 из 17 (59 %) пациентов. У них всех тракты (SLF / AF, FAT, IFOF) либо примыкали к опухоли, либо находились в пределах 4 мм от ее края. Развившиеся речевые нарушения регрессировали в течение первых 3 мес после операции, и только в одном наблюдении сформировался стойкий неврологический дефицит. Заключение. Применение кортикальной и субкортикальной стимуляции (монополярная, биполярная стимуляция) в хирургии глиальных опухолей доминантного полушария головного мозга позволяет добиться высокой радикальности удаления опухоли с минимальным риском развития после операции постоянного дефицита речи. Транзиторные нарушения речи после операции наблюдались у всех пациентов, у которых по данным предоперационной трактографии ассоциативные тракты (SLF / AF, FAT, IFOF) располагались не далее 4 мм от края опухоли.
Altered thalamotemporal structural connectivity is associated with autistic traits in children with ASD
2025 · ARTICLE · en
Background Thalamocortical functional and structural connectivity alterations may contribute to clinical phenotype of Autism Spectrum Disorder (ASD). As previous studies focused mainly on thalamofrontal connections in ASD, we comprehensively investigated the thalamic functional networks and white matter pathways projecting also to temporal, parietal, occipital lobes and their associations with core and co-occurring conditions of this population. Methods A total of 38 children (19 with ASD) underwent magnetic resonance imaging and behavioral assessment. Functional and structural scans were processed to analyze between-group thalamic connectivity differences and their relationships to measurements of autistic traits and language abilities. Results No functional differences were found between groups across 20 networks in each hemisphere. However, we showed that the diffusion properties of thalamocortical pathways projecting to the right and left temporal lobes were disrupted in children with ASD. Additionally, there was a significant association between diffusion differences of thalamotemporal tracts and severity of autistic traits. Conclusions Our findings on altered thalamotemporal structural but not functional connectivity contribute to the understanding of white matter organization of thalamocortical pathways in children with ASD.
Atypical Social Behavior is Predicted by Overconnectivity Between Salience and Default Mode Networks in Autism Spectrum Disorder
2025 · ARTICLE · en
As Default Mode and Salience networks (DMN, SN) contribute to social behavior and switching between inner and outer attention, they are believed to function and develop differently in individuals with Autism Spectrum Disorder (ASD). However, it remains unclear what alterations of their interactivity are connected to certain autistic traits and how age influences these networks’ maturing. Behavioral (social responsiveness, executive functions and communication skills) and resting-state functional connectivity (FC) data from the Autism Brain Imaging Data Exchange were analyzed comprising individuals with ASD (n = 144) and healthy controls (n = 99). We compared FC between the groups investigating DMN and SN separately and in combination. Finally, we assessed FC-behavior links in the ASD group and age effects on FC across these networks in both samples. Individuals with ASD exhibited increased FC between DMN and SN but decreased one within DMN compared to the control group. FC between right insular and medial prefrontal cortices predicted more severe social responsiveness impairments in ASD but there were no significant associations with executive functions nor adaptive behavior. Additionally, DMN and SN matured in ASD with partly different patterns than in typical development. Our results replicated and expanded previous findings on DMN and SN pointing to robust differences within and between these networks in ASD and their contribution to autistic traits regarding social responsiveness.
Интраоперационное картирование речи во время операций с пробуждением
2025 · ARTICLE · ru
Картирование речи во время нейрохирургических операций с пробуждением применяется для определения функционально значимых речевых зон. Несмотря на широкое использование этого метода в мировой практике, на данный момент существует ограниченное количество батарей интраоперационных заданий, которые были бы направлены на тестирование различных подфункций речи. Данный обзор литературы ставит целью описать корковые и подкорковые представительства речи, представить основные тесты, использующиеся для мониторинга речевых функций у пациентов во время операций с пробуждением, и показать специфичность речевых регионов мозга к разным типам заданий.
Atypical segregation of frontoparietal and sensorimotor networks is related to social and executive function impairments in children with ASD
2025 · ARTICLE · en
Two possible indicators of a deficient segregation of functional networks are within-underconnectivity and between-overconnectivity. Both these processes can be observed in Autism Spectrum Disorder (ASD) to be associated with different core and co-occurring atypicalties of behavior. We focused on within- and between-network connectivity of Frontoparietal and Sensorimotor networks in ASD compared to typically developed (TD) peers and its links to social difficulties and impairments of executive and motor functions. To our knowledge, this study for the first time described between-network connectivity of Frontoparietal and Sensorimotor networks in ASD with relations to symptoms of ASD. In this study, we utilised resting-state functional MRI to investigate 121 participants with ASD and 84 TD children. We investigated between-group differences of the connectivity between Frontoparietal and Sensorimotor regions. We also conducted brain-behavior analysis for beta values of these connections and behavioral scores. Controlling for age and sex, we found a significant group difference within- Frontoparietal network (right and left posterior parietal cortices were underconnected in ASD) and between-networks (right posterior parietal and right lateral sensorimotor cortices were overconnected in ASD). In the ASD group, we also showed that within-Frontoparietal underconnectivity was related to lower scores of social and executive functions as well as between-networks overconnectivity was associated with social difficulties only. There were no significant relationships between scores of motor functions and beta values. We confirmed the hypothesis of deficient segregation for Frontoparietal and Sensorimotor networks in ASD. These findings highlight the importance of between-network connectivity investigation.
Left-hemispheric atypicalities in the primary auditory cortex are associated with language comprehension and social skills in children with Autism Spectrum Disorder
2025 · ARTICLE · en
Low-level auditory processing difficulties have been previously reported in children with Autism Spectrum Disorder (ASD), and some studies showed the relationship between these difficulties in the primary auditory cortex and language impairment in ASD. However, there is still a limited number of studies that comprehensively assess (i) amplitudes, latencies, and sensory gating effects in all early components of auditory processing (M50-M100-M200 complex) at the source level in magnetoencephalography with their relation to structural anatomy (gray matter volume, thickness, gyrification) (ii) and the association between brain metrics and clinical phenotype in the same group of children. To address this question, we used a standard paired-clicks paradigm in magnetoencephalography and brain morphometry analysis in children with and without ASD (NASD = 20, NTD = 20). First, the results revealed a reduction of M200 and altered M200 sensory gating effect in the left auditory cortex in children with ASD. Second, these alterations were related to lower language comprehension skills and higher autistic symptom severity. Finally, altered MEG responses were associated with gray matter thickness reduction as well as abnormal gyrification in the primary auditory cortex in ASD. The study revealed low-level functional and structural atypicalities in children with ASD and their relation to clinical phenotype.
How well can simple clinical features predict long-term language recovery after left-hemisphere glioma surgery?
2025 · ARTICLE · en
Purpose Long-term language recovery after left-hemisphere glioma surgery varies substantially across patients. We investigated how well it can be predicted using clinical variables such as the postoperative decline in language processing, tumor grade, resection volume and location, extent of resection, and intraoperative language mapping. Beyond predicting the overall recovery, we examined which domains of language processing are most prone to persistent deficits. Methods Fifty-nine patients with left-hemisphere gliomas completed the Russian Aphasia Test (RAT) before surgery, immediately after surgery, and at follow-up three to seventeen months after surgery. We modeled their average language score (Generalized Aphasia Quotient, GAQ) at follow-up using a cross-validated multiple linear regression and calculated the number of patients showing persistent deficits in each subtest of the RAT. Results The difference between GAQ scores at follow-up and before surgery was not significant at the group level but varied substantially across patients (mean −1.3%, range −34.2 – 9.2%). Our best-performing model predicted the follow-up GAQ scores with the mean absolute error of 3.5% (cross-validated R2 = 0.15). A greater decline in language processing immediately after surgery predicted worse recovery, whereas intraoperative language mapping predicted better recovery. Deficits in sentence repetition, verb production, verb and sentence comprehension, and object naming most often persisted at follow-up. Conclusion The postoperative decline in language processing and intraoperative language mapping explain a substantial amount of variability in long-term language recovery. Verbal working memory and lexical retrieval, particularly that of verbs, are most prone to persistent deficits.
Discourse Diversity Database (3D) for Clinical Linguistics Research: Design, Development, and Analysis
2023 · ARTICLE · en
Discourse Diversity Database (3D) is a corpus designed for clinical linguistics research. It consists of oral speech samples of three different genres: picture-elicited narratives, personal stories, and picture-based instructions. The sub-sections of 3D include recordings by Russian speakers from three independent groups: people with brain tumors before and after tumor removal, people with schizophrenia, and neurologically healthy individuals. This article is devoted to the description of the data collection, the annotation scheme, and the specific characteristics of each sub-section of the corpus.
Инструмент измерения функциональных коммуникативных навыков и сопоставление его с традиционным речевым тестированием у пациентов с опухолями головного мозга
2023 · ARTICLE · ru
Афазии, возникающие вследствие очагового поражения головного мозга, значительно снижают качество жизни пациентов. Своевременная диагностика нарушений речи может способствовать планированию эффективной терапии речи. При этом особое значение имеют шкалы, направленные на оценку функциональной коммуникации. Цель настоящего исследования заключалась в выявлении взаимосвязи между речевыми нарушениями, измеренными Русским афазиологическим тестом, и функциональной коммуникацией, оцененной Индексом коммуникативной эффективности. Тестирование РАТ и ИКЭФ было проведено у 87 пациентов в двух временных точках, до операции и через 3 месяца после операции. В данном исследовании впервые представлена русская версия Индекса коммуникативной эффективности и подтверждена взаимосвязь между речевыми нарушениями, измеренными комплексной стандартизированной батареей для оценки речевого статуса (Русским афазиологическим тестом), и функциональной коммуникацией, оцененной Индексом коммуникативной эффективности.
Corpus callosum organization and its implication to core and co-occurring symptoms of Autism Spectrum Disorder
2023 · ARTICLE · en
Autism Spectrum Disorder (ASD) is characterized by social interaction and communication deficits, repetitive behavior and often by co-occurring conditions such as language and non-verbal IQ development delays. Previous studies reported that those behavioral abnormalities can be associated with corpus callosum organization. However, little is known about the specific differences in white matter structure of the corpus callosum parts in children with ASD and TD peers and their relationships to core and co-occurring symptoms of ASD. The aim of the study was to investigate the volumetric and microstructural characteristics of the corpus callosum parts crucially involved in social, language, and non-verbal IQ behavior in primary-school-aged children with ASD and to assess the relationships between these characteristics and behavioral measures. 38 children (19 with ASD and 19 typically developing (TD) controls) were scanned using diffusion-weighted MRI and assessed with behavioral tests. The tractography of the corpus callosum parts were performed using Quantitative Imaging Toolkit software; diffusivity and volumetric measurements were extracted for the analysis. In the ASD group, fractional anisotropy (FA) was decreased across the supplementary motor area and the ventromedial prefrontal cortex, and axial diffusivity (AD) was reduced across each of the corpus callosum parts in comparison to the TD group. Importantly, the AD decrease was related to worse language skills and more severe autistic traits in individuals with ASD. The microstructure of the corpus callosum parts differs between children with and without ASD. Abnormalities in white matter organization of the corpus callosum parts are associated with core and co-occurring symptoms of ASD.
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Психо- и нейролингвистика · 4 раза
2025/2026, 2024/2025, 2023/2024, 2022/2023 · Бакалавриат · рус
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Психо- и нейролингвистический практикум · 3 раза
2025/2026, 2024/2025, 2023/2024 · Бакалавриат · рус