Штыров Юрий Юрьевич
Институт когнитивных нейронаук
Профессиональные интересы
Должности
- Директор центра — Институт когнитивных нейронаук, Центр исследований интеллекта и когнитивного благополучия
- Ведущий научный сотрудник — Институт когнитивных нейронаук, Центр исследований интеллекта и когнитивного благополучия
- Ведущий научный сотрудник — Институт когнитивных нейронаук, Центр нейроэкономики и когнитивных исследований
Био
- · Начал работать в НИУ ВШЭ в 2013 году.
- · Научно-педагогический стаж: 25 лет.
Образование
- 2001 · PhD: Университет Хельсинки
- 1994 · Специалитет: Санкт-Петербургский государственный университет, специальность «Физиология», квалификация «Биолог-физиолог»
Опыт работы
- · Yury Shtyrov (Professor, Head of MEG/EEG at the Center of Functionally Integrative Neuroscience, Aarhus University; Visiting Professor/PI at the HSE CDM Centre) has many years of international experience in studying human neurocognitive functions, in particular neurobiological foundations of the human speech and language function. His particular contribution to the science of language has been in uncovering early and automatic stages of language processing and in detailing the time course of spoken language comprehension in the brain. This work has to a large extent contributed to a dramatic change in our understanding of how the brain analyses speech, which has occurred in recent years. It shows how memory traces for linguistic elements in the brain can be probed using objective imaging tools, how they develop with learning, interact on different levels, as well as the interaction between the cognitive systems of language and attention. Most importantly, this work shows that these different processes occur rapidly and in parallel, something that was first met with disbelief but is now becoming generally accepted thanks to this and similar work. We are very pleased to have Prof. Shtyrov as our close collaborator in a range of projects focussed on human mechanisms of comminication, perception and cognitive control using MEG, EEG, TMS, behavioural and other methodologies.
- · 2013–настоящее время Professor - Head of MEG Group MINDLab - Centre for Functionally Integrative Neuroscience (CFIN) Institute for Clinical Medicine Aarhus University, Denmark
- · 2011–2012: Professor - Director of the Cognitive Brain Research Unit at the IBS - Universityof Helsinki, Institute of Behavioural Sciences (IBS), Helsinki, Finland
- · 2007–2013: Senior Scientist (Programme Leader Track) and Head of Magneto- and Electroencephalography (since 2011) - Medical Research Council (MRC), Cognition and Brain Sciences Unit. Cambridge, United Kingdom
- · 2000–2007: Research Associate (Post-Doctoral Research Scientist)
- · 2000-2003: / Senior Investigator Scientist
- · 2003-2007: Since
- · 2006: also MEG Lab Manager - MRC Cognition and Brain Sciences Unit. Cambridge, United Kingdom
- · 1997–2000: Researcher - Cognitive Brain Research Unit, University of Helsinki, Helsinki,Finland
- · 1994–1997: Младший научный сотрудник - Отдел физиологии и патологии речи, СПб НИИ Уха, Горла, Носа и Речи. Санкт-Петербург, Россия
Награды и поощрения
- · Благодарственное письмо ректора НИУ ВШЭ (сентябрь 2021)
- · Надбавка за публикацию в журнале из Списка А (и приравненном к нему научном издании) (2025–2026)
- · Надбавка за публикацию в международном рецензируемом научном издании (2021–2022)
Гранты и проекты
- 2015 · AUFF Research Foundation, Denmark, 2014. PI on a 6-month visiting professorship grant, DKK 284 000, 2014-2015.
- 2017 · Lundbeck Foundation, Denmark, 2014. PI on 3-year project grant: Neural Speech Processing as Covert Index of Consciousness in Coma, Vegetative State, and Minimally Conscious Patients. DKK ~1.6 mln (~€ 210 000), 2014-2017.
- 2016 · Lundbeck Foundation, Denmark, 2013. PI on 3-year project grant: Rapid formation of lexical memory circuits in human neocortex. DKK 3 mln (~€ 400 000), 2014-2016.
- — · Pufendorf Institute, Lund, Sweden, 2013. HuMeNs - – Advanced Study Group on neuroscience of knowledge acquisition. Co-applicants: Profs. M. Lindgren, M. Horne, F. Ståhlberg, D Topgaard et al. (Lund U), ~100000 SEK.
- 2017 · Engineering and Physical Sciences Research Council & Medical Research Council, UK, 2012. Co-PI on 5-year partnership programme grant: Building capacity in UK clinical MEG research. Co-applicants: Profs K. Singh (U Cardiff), K. Nobre (U Oxford), Dr G. Barnes (UCL) et al. ~£1.3 mln. 2013-2017.
- 2013 · European Commission Tempus IV programme, 2010. Co-PI on a 3.5-year project grant: Postgraduate training network in biotechnology of 3.5-year project grant. Co-applicants: K. Kaila, (Helsinki U)., I. Pavlov (UCL), A. Shestakova (St. Petersburg U.), V. Klucharev (FC Donders) et al. ~€ 1 mln. 2010-2013.
- 2011 · Federal Agency for Science and Innovation, Russian Federation, 2010. PI on a 2-year project grant №02.740.11.5148: Introduction of novel methodologies into science, medicine and education in RF: using magnetoencephalography for mapping brain function. RUB 2 mln. 2010-2011.
- 2014 · Medical Research Council, UK, 2009. PI on 5-year research programme U.1055.04.014.00001.01: Early automaticity of neural language processing: lexical, morphosyntactic and methodological perspectives. ~£1.4 mln. 2009-2014.
- 2011 · GlaxoSmithKline, UK, 2009. Co-PI on a 2-year industrial collaborative research programme: Biomarkers of schizophrenia. PIs: Profs F. Pulvermuller & Y. Shtyrov. £ 150 000, 2009-2011.
- 2016 · Elekta Neuromag Ltd, Sweden-Finland, 2006. Co-PI on a 10-year industrial research collaboration programme: Clinical utility of magnetoencephalography. PIs: Profs F. Pulvermuller, Y. Shtyrov, R. Henson. £ 100 000. 2007-2016.
- 2009 · European Commission Tempus programme, 2005. Co-PI on a 3.5-year project grant. Co-applicants: Drs I. Pavlov (UCL), A. Shestakova (Helsinki U.), O. Pongs (Hamburg U.), V. Klucharev (FC Donders), I. Kanunikov (St. Petersburg U.). € 500 000. 2006-2009.
- 2003 · Finnish Graduate School of Psychology, 1999. Four-year PhD research fellowship, FIM 400 000. 1999-2003.
- 2000 · Cognitive Brain Research Unit, University of Helsinki, Finland, 1998. Two-year research grant, funded by the Finnish Work Environment Fund. Co-applicant: Dr. T. Kujala. FIM 300 000. 1998-2000
- 1999 · University of Helsinki, Finland, 1998. Six-month personal grant. FIM 9 000. 1998-1999
- — · Centre for International Mobility, Finland, 1998. Six-month personal research grant. FIM 36 000
- 1998 · Centre for International Mobility, Finland, 1997. One-year personal research grant. FIM 60 000. 1997-1998.
Конференции (5)
Показать все
- · 2025: CogSci2025 (Сан-Франциско). Доклад: Age-related changes in cognitive flexibility: fMRI meta‐analysis
- · 2018: 24th AMLaP conference, Architectures and Mechanisms of Language Processing (Берлин). Доклад: PERCEPTUAL PRIMING AND SYNTACTIC CHOICE IN ENGLISH LANGUAGE: MULTIMODAL STUDY.
- · 2018: 24th AMLaP conference, Architectures and Mechanisms of Language Processing (Берлин). Доклад: PERCEPTUAL PRIMING AND SYNTACTIC CHOICE IN RUSSIAN LANGUAGE: MULTIMODAL STUDY.
- · 2017: 5th Polish Eye Tracking Conference (Люблин). Доклад: The role of attention in sentence production: beyond visual modality
- · 2016: 8th Annual Meeting of the Society for the Neurobiology of Language (Лондон). Доклад: The effects of cross-linguistic phonologic and semantic overlap in masked priming paradigm: behavioral and ERP evidence
Идентификаторы исследователя
- ORCID:
0000-0001-7203-4902 - ResearcherID:
I-3421-2013 - Google Scholar: https://scholar.google.ru/citations?user=VqgPbV0AAAAJ&hl=en
- Scopus AuthorID:
6701617874
Публикации (155)
Flexible, rapid and automatic neocortical word form acquisition mechanism in children as revealed by neuromagnetic brain response dynamics
2017 в печати · ARTICLE · en
Children learn new words and word forms with ease, often acquiring a new word after very few repetitions. Recent neurophysiological research on word form acquisition in adults indicates that novel words can be acquired within minutes of repetitive exposure to them, regardless of the individual's focused attention on the speech input. Although it is well-known that children surpass adults in language acquisition, the developmental aspects of such rapid and automatic neural acquisition mechanisms remain unexplored. To address this open question, we used magnetoencephalography (MEG) to scrutinise brain dynamics elicited by spoken words and word-like sounds in healthy monolingual (Danish) children throughout a 20-min repetitive passive exposure session. We found rapid neural dynamics manifested as an enhancement of early (~100 ms) brain activity over the short exposure session, with distinct spatiotemporal patterns for different novel sounds. For novel Danish word forms, signs of such enhancement were seen in the left temporal regions only, suggesting reliance on pre-existing language circuits for acquisition of novel word forms with native phonology. In contrast, exposure both to novel word forms with non-native phonology and to novel non-speech sounds led to activity enhancement in both left and right hemispheres, suggesting that more wide-spread cortical networks contribute to the build-up of memory traces for non-native and non-speech sounds. Similar studies in adults have previously reported more sluggish (~15–25 min, as opposed to 4 min in the present study) or non-existent neural dynamics for non-native sound acquisition, which might be indicative of a higher degree of plasticity in the children's brain. Overall, the results indicate a rapid and highly plastic mechanism for a dynamic build-up of memory traces for novel acoustic information in the children's brain that operates automatically and recruits bilateral temporal cortical circuits.
Cortical networks for reference-frame processing are shared by language and spatial navigation systems
2017 · ARTICLE · en
To help us live in the three-dimensional world, our brain integrates incoming spatial information into reference frames, which are based either on our own body (egocentric) or independent from it (allocentric). Such frames, however, may be crucial not only when interacting with the visual world, but also in language comprehension, since even the simplest utterance can be understood from different perspectives. While significant progress has been made in elucidating how linguistic factors, such as pronouns, influence reference frame adoption, the neural underpinnings of this ability are largely unknown. Building on the neural reuse framework, this study tested the hypothesis that reference frame processing in language comprehension involves mechanisms used in navigation and spatial cognition. We recorded EEG activity in 28 healthy volunteers to identify spatiotemporal dynamics in (1) spatial navigation, and (2) a language comprehension task (sentence-picture matching). By decomposing the EEG signal into a set of maximally independent activity patterns, we localised and identified a subset of components which best characterised perspective-taking in both domains. Remarkably, we find individual co-variability across these tasks: people's strategies in spatial navigation are also reflected in their construction of sentential perspective. Furthermore, a distributed network of cortical generators of such strategy-dependent activity responded not only in navigation, but in sentence comprehension. Thus we report, for the first time, evidence for shared brain mechanisms across these two domains - advancing our understanding of language's interaction with other cognitive systems, and the individual differences shaping comprehension. © 2017 Elsevier Inc
MOTOR (BUT NOT AUDITORY) ATTENTION AFFECTS SYNTACTIC CHOICE
2017 · PREPRINT · en
Understanding the determinants of syntactic choice in sentence production is a salient topic in psycholinguistics. Existing evidence suggests that syntactic choice results from an interplay between linguistic and non-linguistic factors, and a speaker’s attention to the elements of a described event represents one such factor. Whereas multimodal accounts of attention suggest a role for different modalities in this process, existing studies examining attention effects in syntactic choice are primarily based on visual cueing paradigms. Hence, it remains unclear whether attentional effects on syntactic choice are limited to the visual modality or may be subject to cross-modal interaction. The current study addressed this issue. Native English participants viewed and described line drawings of simple transitive events while their attention was directed to the location of the agent or the patient of the depicted event by means of either an auditory (monaural beep) or a motor (unilateral key press) lateral cue. Our results show an effect of cue location, with participants producing more passive-voice descriptions in the patient-cued conditions. Crucially, this cue location effect emerged in the motor-cue but not in the auditory-cue condition, as confirmed by a reliable interaction between cue location (agent vs. patient) and cue type (auditory vs. motor). Our data suggest that attentional effects on the speaker’s syntactic choices are modality dependent and appear to be more prominent in the visuomotor domain than in the auditory domain.
TRANSCRANIAL DIRECT CURRENT STIMULATION AS A TOOL TO INDUCE LANGUAGE RECOVERY IN PATIENTS WITH POST-STROKE APHASIA: AN OVERVIEW OF STUDIES
2017 · PREPRINT · en
In recent years, possible therapeutic effects of transcranial direct current stimulation (tDCS) have been widely investigated in studies of different types of neural pathologies. Recent reviews of tDCS in patients with post-stroke aphasia did not provide coherent evidence oа its efficiency. There were no uniform protocols of stimulation, patient selection criteria were highly divergent, and the reports of treatment outcomes varied dramatically. In this review, we focus on the reported heterogeneity of tDCS effects trying to disentangle its putative underpinnings rooted in the diversity of lesion types, aphasia severity and recovery stages. Given the current theoretical models suggesting qualitatively different patterns of brain activity which accompany aphasia recovery, various physiological factors should be taken into account to choose optimal tDCS parameters. With this in mind, we assess the results of ten studies applying tDCS in post-stroke aphasia treatment, and suggest directions for further research in this rapidly developing field.
Hemispheric contributions to language reorganisation: An MEG study of neuroplasticity in chronic post stroke aphasia
2016 в печати · ARTICLE · en
Previous studies have demonstrated that efficient neurorehabilitation in post stroke aphasia leads to clinical language improvements and promotes neuroplasticity. Brain areas frequently implicated in functional restitution of language after stroke comprise perilesional sites in the left hemisphere and homotopic regions in the right hemisphere. However, the neuronal mechanisms underlying therapy-induced language restitution are still largely unclear. In this study, magnetoencephalography was used to investigate neurophysiological changes in a group of chronic aphasia patients who underwent intensive language action therapy (ILAT), also known as constraint-induced aphasia therapy (CIAT). Before and immediately after ILAT, patients’ language and communication skills were assessed and their brain responses were recorded during a lexical magnetic mismatch negativity (MMNm) paradigm, presenting familiar spoken words and meaningless pseudowords. After the two-week therapy interval, patients showed significant clinical improvements of language and communication skills. Spatio-temporal dynamics of neuronal changes revealed a significant increase in word-specific neuro-magnetic MMNm activation around 200 ms after stimulus identification points. This enhanced brain response occurred specifically for words and was most pronounced over perilesional areas in the left hemisphere. Therapy-related changes in neuromagnetic activation for words in both hemispheres significantly correlated with performance on a clinical language test. The findings indicate that functional recovery of language in chronic post stroke aphasia is associated with neuroplastic changes in both cerebral hemispheres, with stronger left-hemispheric contribution during automatic stages of language processing.
First-pass neocortical processing of spoken language takes only 30 msec: Electrophysiological evidence
2016 в печати · ARTICLE · en
Fast real-time processing of external information by the brain is vital to survival in a highly dynamic environment. A ubiquitous information medium used by humans is spoken language, but the neural dynamics of its comprehension is still poorly understood. Here, we scrutinized the earliest electrophysiological activity elicited in the human brain by spoken words and matched meaningless word-like stimuli using a lexical auditory oddball paradigm, an established technique for investigating cortical activation patterns underlying early automatic stages of language processing. We show that the earliest cortical reflection of word comprehension takes place during the electrophysiological P1 evoked response, at about 30 ms following the word disambiguation point, and takes the form of an enhanced brain activation for familiar meaningful words, even when they are presented outside the focus of attention. This previously unknown ultra-early lexicality effect is underpinned by left temporo-frontal cortical circuits and likely reflects a first-pass automatic lexical access that precedes later stages of lexical and semantic processing described in previous literature. The results suggest that the brain operates with maximum speed and efficiency to extract meaningful (including linguistic) information from the sensory input, which is a neurobiological capacity essential for timely and appropriate reactions to external events.
Near-instant automatic access to visually presented words in the human neocortex: Neuromagnetic evidence
2016 · ARTICLE · en
Rapid and efficient processing of external information by the brain is vital to survival in a highly dynamic environment. The key channel humans use to exchange information is language, but the neural underpinnings of its processing are still not fully understood. We investigated the spatio-temporal dynamics of neural access to word representations in the brain by scrutinising the brain’s activity elicited in response to psycholinguistically, visually and phonologically matched groups of familiar words and meaningless pseudowords. Stimuli were briefly presented on the visual-field periphery to experimental participants whose attention was occupied with a non-linguistic visual feature-detection task. The neural activation elicited by these unattended orthographic stimuli was recorded using multi-channel whole-head magnetoencephalography, and the timecourse of lexically-specific neuromagnetic responses was assessed in sensor space as well as at the level of cortical sources, estimated using individual MR-based distributed source reconstruction. Our results demonstrate a neocortical signature of automatic near-instant access to word representations in the brain: activity in the perisylvian language network characterised by specific activation enhancement for familiar words, starting as early as ~70 ms after the onset of unattended word stimuli and underpinned by temporal and inferior-frontal cortices.
Reduced volume of the arcuate fasciculus in adults with high-functioning autism spectrum conditions
2016 · ARTICLE · en
Atypical language is a fundamental feature of autism spectrum conditions (ASC), but few studies have examined the structural integrity of the arcuate fasciculus, the major white matter tract connecting frontal and temporal language regions, which is usually implicated as the main transfer route used in processing linguistic information by the brain. Abnormalities in the arcuate have been reported in young children with ASC, mostly in low-functioning or non-verbal individuals, but little is known regarding the structural properties of the arcuate in adults with ASC or, in particular, in individuals with ASC who have intact language, such as those with high-functioning autism or Asperger syndrome. We used probabilistic tractography of diffusion-weighted imaging to isolate and scrutinize the arcuate in a mixed-gender sample of 18 high-functioning adults with ASC (17. Asperger syndrome) and 14 age-and IQ-matched typically developing controls. Arcuate volume was significantly reduced bilaterally with clearest differences in the right hemisphere. This finding remained significant in an analysis of all male participants alone. Volumetric reduction in the arcuate was significantly correlated with the severity of autistic symptoms as measured by the Autism-Spectrum Quotient. These data reveal that structural differences are present even in high-functioning adults with ASC, who presented with no clinically manifest language deficits and had no reported developmental language delay. Arcuate structural integrity may be useful as an index of ASC severity and thus as a predictor and biomarker for ASC. Implications for future research are discussed. © 2016 Moseley, Correia, Baron-Cohen, Shtyrov, Pulvermüller and Mohr.
Individual language experience modulates rapid formation of cortical memory circuits for novel words
2016 · ARTICLE · en
Mastering multiple languages is an increasingly important ability in the modern world; furthermore, multilingualism may affect human learning abilities. Here, we test how the brain’s capacity to rapidly form new representations for spoken words is affected by prior individual experience in non-native language acquisition. Formation of new word memory traces is reflected in a neurophysiological response increase during a short exposure to novel lexicon. Therefore, we recorded changes in electrophysiological responses to phonologically native and non-native novel word-forms during a perceptual learning session, in which novel stimuli were repetitively presented to healthy adults in either ignore or attend conditions. We found that larger number of previously acquired languages and earlier average age of acquisition (AoA) predicted greater response increase to novel non-native word-forms. This suggests that early and extensive language experience is associated with greater neural flexibility for acquiring novel words with unfamiliar phonology. Conversely, later AoA was associated with a stronger response increase for phonologically native novel word-forms, indicating better tuning of neural linguistic circuits to native phonology. The results suggest that individual language experience has a strong effect on the neural mechanisms of word learning, and that it interacts with the phonological familiarity of the novel lexicon.
Acquisition and consolidation of novel morphology in human neocortex: A neuromagnetic study
2016 · ARTICLE · en
Research into neurobiological mechanisms of morphosyntactic processing of language has suggested specialised systems for decomposition and storage, which are used flexibly during the processing of complex polymorphemic words (such as those formed through affixation, e.g., boy + s = noun + plural marker or boy + ish = noun plus attenuator). However, neural underpinnings of acquisition of novel morphology are still unknown. We implicitly trained our participants with new derivational affixes through a word–picture association task and investigated the neural processes underlying formation of neural memory traces for new affixes. The participants' brain activity was recorded using magnetoencephalography (MEG), as they passively listened to the newly trained and untrained suffixes combined with real word and pseudoword stems. The MEG recording was repeated after a night's sleep using the same stimuli, to test the effects of overnight consolidation. The newly trained suffixes combined with real stems elicited stronger source activity in the left inferior frontal gyrus (LIFG) at ∼50 msec after the suffix onset than untrained suffixes, suggesting memory trace formation for the newly learned suffixes already on the same day. The following day, the suffix learning effect spread to the left superior temporal gyrus (STG) where it was again manifest as a response enhancement, particularly at ∼200–300 msec after the suffix onset, which might reflect an additional effect of overnight consolidation. Overall, the results demonstrate the rapid and dynamic processes of both immediate build-up and longer-term consolidation of neocortical memory traces for novel morphology, taking place after a short period of exposure to novel morphology and involving fronto-temporal perisylvian language circuitry.
Курсы (0)
Нет курсов.