Гергес Марина Малак Бешара
Институт когнитивных нейронаук
Должности
- Аспирант — Институт когнитивных нейронаук, Международная лаборатория социальной нейробиологии
- Младший научный сотрудник — Институт когнитивных нейронаук, Центр нейроэкономики и когнитивных исследований
Био
- · Начала работать в НИУ ВШЭ в 2025 году.
Идентификаторы исследователя
- ORCID:
0000-0002-5946-1982 - ResearcherID:
LRU-0626-2024
Публикации (4)
Emotion Regulation in Overeating Disorders: A Psychophysiological Study
2026 в печати · ARTICLE · en
Objectives: Maladaptive eating behaviors characterize overeating disorders and are often accompanied by emotion dysregulation. Physiological mechanisms remain poorly understood. This study investigated psychophysiological responses to food-related, aversive, and neutral stimuli under different emotion regulation strategies. Methods: Sixty-four adults (75% female; mean age = 45.6 years) with BMI ≥ 25 kg/m² participated (50 with overeating disorder, 14 healthy controls). Participants viewed food, aversive, and neutral pictures under watch, reappraisal, and expressive suppression conditions while heart rate, skin conductance, and facial electromyography were recorded. Subjective valence and craving ratings were collected. Results: Overeating participants showed heightened skin conductance response (p = 0.030) and a negativity bias for aversive stimuli (valence × aversive picture interaction, p = 0.001). For food stimuli, they demonstrated smaller heart rate deceleration than controls (p = 0.009). Emotion regulation strategies did not significantly alter physiological responses, indicating a lack of regulatory flexibility in the overeating group. Conclusions: Overeating participants display distinct psychophysiological profiles characterized by increased emotional reactivity, blunted cardiac responses to food cues, and heightened negative emotional sensitivity. The absence of modulation by standard strategies suggests regulatory inflexibility.
Biochemical Foundations of Emotion Regulation: Implications for Pharmacological and Psychological Interventions-A Narrative Review
2025 · ARTICLE · en
Background: Emotional regulation (ER) involves processes that modulate the intensity, duration, and expression of emotions. Dysregulation in ER is closely linked to mental health disorders, highlighting the need to understand its biochemical foundations. While traditionally studied from psychological perspectives, ER is increasingly recognized as deeply intertwined with biochemical pathways. Objective: This review aims to explore the biochemical underpinnings of ER, focusing on the bidirectional relationship between biochemical mediators and emotion regulation processes, and examining how these interactions influence mental health and therapeutic interventions. Methods: A comprehensive review of relevant studies was conducted to synthesize evidence on the roles of neurotransmitters (e.g., serotonin, dopamine, GABA) and hormones (e.g., cortisol, oxytocin) in ER. The review also evaluates the effects of ER strategies (e.g., cognitive reappraisal, expressive suppression) on physiological markers such as cortisol and inflammatory cytokines, as well as the impact of pharmacological treatments (e.g., antidepressants, mood stabilisers) and substances (e.g., alcohol, illicit drugs) on ER. Results: Key neurotransmitters and hormones play pivotal roles in shaping emotional responses. Dysregulated emotional states alter biochemical markers, creating a feedback loop between emotional and physiological systems. Adaptive ER strategies, such as cognitive reappraisal and mindfulness, are associated with improved biochemical profiles, while maladaptive strategies like expressive suppression are linked to adverse physiological outcomes. Pharmacological interventions enhance ER by restoring balance in brain circuits, whereas substances impair ER by disrupting neurotransmitter systems. Conclusion: The interplay between biochemical processes and ER provides critical insights into the mechanisms underlying mental disorders and informs the development of targeted therapeutic interventions. Further research is needed to refine these insights and translate findings into effective clinical applications.
Advancing affective stimuli databases: challenges and solutions
2025 · ARTICLE · en
Affective stimulus databases are integral elements in psychological and neuroscientific research, enabling the controlled induction of emotional states. However, despite significant progress, existing databases face methodological limitations that interfere with cross- study comparability and reproducibility. This review thoroughly examines modern affective stimulus databases across visual, auditory, textual, and multimodal domains, presenting their positive attributes and deficiencies. Key challenges include variability in stimulus standardization, inconsistencies in validation procedures, cultural specificity, and reliance on either categorical or dimensional emotion assessment methods. Additionally, issues related to stimulus diversity, duration control, and ecological validity further complicate the interpretation of results in psychophysiological studies. To address these challenges, we propose strategies for improving future databases, including the integration of standardized evaluation methodologies, the expansion of multimodal and culturally diverse stimuli, and the implementation of advanced technological solutions such as virtual reality and machine learning. Improving the structure of databases and maintaining consistent methodologies will increase the reliability and applicability of emotion research, ultimately contributing to a more comprehensive understanding of affective processes across different fields.
Biochemical Foundations of Emotion Regulation: Implications for Pharmacological and Psychological Interventions-A Narrative Review
2025 · ARTICLE · en
Emotion regulation (ER) involves processes by which individuals modulate the intensity, duration, and expression of emotional responses, and its dysregulation is associated with a broad spectrum of psychological disorders. While traditionally conceptualized within psychological frameworks, ER is increasingly recognized as biologically grounded, involving intricate interactions between neurochemical, hormonal, and metabolic systems. This narrative review aims to synthesize current evidence on biochemical substrates of ER, with a specific focus on integrating findings across neurotransmitters (serotonin, dopamine, GABA, glutamate), classical regulatory hormones (cortisol, oxytocin), and metabolic hormones (leptin, ghrelin, insulin). We critically examine how these systems interact with both adaptive and maladaptive ER strategies, and how they are modulated by pharmacological treatments (e.g., antidepressants, mood stabilizers) and substances (e.g., alcohol, illicit drugs). A particular contribution of this review lies in its emphasis on metabolic hormones. This domain remains underrepresented in mainstream ER models despite emerging relevance in stress reactivity and emotion-linked behavior. Although evidence suggests compelling associations, much of the existing research remains correlational, and further longitudinal studies are warranted. Although structured to capture key developments, the narrative design may not encompass every relevant study, and variations in methodologies across research contexts suggest that comparisons should be interpreted with caution. Nevertheless, this work identifies conceptual gaps and outlines practical implications, including the potential to tailor interventions based on individual neurochemical and behavioral profiles.
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